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→Chosing the correct variants to include in the PGx alleles
===Chosing the correct variants to include in the PGx alleles===
The allele definitions from PharmGKB and PharmVar are not always one-to-one, and some background knowledge about why this is, is required. Prefiltering of PharmGKB allele definitions was performed by the [[PGx in Estonia|PGx pipeline of the University of Tartu]], although the exact prefiltering was not published in the supplementary material to [https://www.biorxiv.org/content/early/2018/07/04/356204 ''Reisberg et al.''].
Take as an example that illustrates many of these problems CYP2C19*19:
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