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There are at least three kind of alleles that have unknown-biochemical function
*Known PGx alleles that are classified with unknown functional status by PharmGKB
*Alleles with variants that cause changes to the protein, but which are not classified by PharmGKB*Alleles with variants that do not cause changes to the protein, and which are not classified by PharmGKB
In the CPIC guidelines, some PGx alleles have unknown bio-chemical functional status. The dosing recommendation for such patients is to follow the normal medication advice. There are PGx-alleles that are classified with bio-chemical function, and otherwise, all patients without a known PGx-allele match also have unknown function.
