Difference between revisions of "Unknown function"
Farmakorakel (talk | contribs) |
Farmakorakel (talk | contribs) |
||
| Line 1: | Line 1: | ||
==Alleles with unknown biochemical consequence== | ==Alleles with unknown biochemical consequence== | ||
There are at least three kind of alleles that have unknown biochemical function | There are at least three kind of alleles that have unknown biochemical function | ||
| − | *Known PGx alleles that are classified with | + | *Known PGx alleles that are classified with ''Unknown function'' status by PharmGKB |
*Alleles with variants that cause changes to the protein, but which are not classified by PharmGKB | *Alleles with variants that cause changes to the protein, but which are not classified by PharmGKB | ||
*Alleles with variants that do not cause changes to the protein, and which are not classified by PharmGKB | *Alleles with variants that do not cause changes to the protein, and which are not classified by PharmGKB | ||
| − | + | The dosing recommendation for patients with ''Unknown functional status'' is to follow the normal medication advice. This means that | |
| − | + | *If the patient has an allele with unknown function, the recommended action is to follow normal dosing regime, even if the other allele has ''No function''. | |
| − | |||
==Alleles with normal bio-chemical consequence== | ==Alleles with normal bio-chemical consequence== | ||
The bio-chemical function varies for all patients, and [[Normal function]] just means that the functional status is sufficiently close to the mean that the normal medication recommendation can be used. | The bio-chemical function varies for all patients, and [[Normal function]] just means that the functional status is sufficiently close to the mean that the normal medication recommendation can be used. | ||
| − | There are at least two | + | There are at least two normal |
Revision as of 11:05, 13 July 2018
Alleles with unknown biochemical consequence
There are at least three kind of alleles that have unknown biochemical function
- Known PGx alleles that are classified with Unknown function status by PharmGKB
- Alleles with variants that cause changes to the protein, but which are not classified by PharmGKB
- Alleles with variants that do not cause changes to the protein, and which are not classified by PharmGKB
The dosing recommendation for patients with Unknown functional status is to follow the normal medication advice. This means that
- If the patient has an allele with unknown function, the recommended action is to follow normal dosing regime, even if the other allele has No function.
Alleles with normal bio-chemical consequence
The bio-chemical function varies for all patients, and Normal function just means that the functional status is sufficiently close to the mean that the normal medication recommendation can be used. There are at least two normal
