Difference between revisions of "Unknown function"
Farmakorakel (talk | contribs) |
Farmakorakel (talk | contribs) |
||
| Line 2: | Line 2: | ||
There are at least three kind of alleles that have unknown-biochemical function | There are at least three kind of alleles that have unknown-biochemical function | ||
*Known PGx alleles that are classified with unknown functional status by PharmGKB | *Known PGx alleles that are classified with unknown functional status by PharmGKB | ||
| − | *Alleles with variants that cause changes to the protein | + | *Alleles with variants that cause changes to the protein, but which are not classified by PharmGKB |
| − | *Alleles with variants that do not cause changes to the protein | + | *Alleles with variants that do not cause changes to the protein, and which are not classified by PharmGKB |
| + | |||
| + | |||
In the CPIC guidelines, some PGx alleles have unknown bio-chemical functional status. The dosing recommendation for such patients is to follow the normal medication advice. There are PGx-alleles that are classified with bio-chemical function, and otherwise, all patients without a known PGx-allele match also have unknown function. | In the CPIC guidelines, some PGx alleles have unknown bio-chemical functional status. The dosing recommendation for such patients is to follow the normal medication advice. There are PGx-alleles that are classified with bio-chemical function, and otherwise, all patients without a known PGx-allele match also have unknown function. | ||
Revision as of 10:53, 13 July 2018
Alleles with unknown bio-chemical consequence
There are at least three kind of alleles that have unknown-biochemical function
- Known PGx alleles that are classified with unknown functional status by PharmGKB
- Alleles with variants that cause changes to the protein, but which are not classified by PharmGKB
- Alleles with variants that do not cause changes to the protein, and which are not classified by PharmGKB
In the CPIC guidelines, some PGx alleles have unknown bio-chemical functional status. The dosing recommendation for such patients is to follow the normal medication advice. There are PGx-alleles that are classified with bio-chemical function, and otherwise, all patients without a known PGx-allele match also have unknown function.
Alleles with normal bio-chemical consequence
The bio-chemical function varies for all patients, and Normal function just means that the functional status is sufficiently close to the mean that the normal medication recommendation can be used.
