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At the Farmakorakels Wiki we intend to prestent useful information about pharmacogenomics (PGx) for potential, future use at Oslo University Hospital.

For information about the current state of pharmacogenetics at Oslo University Hospital (in Norwegian), please check out http://www.anx.no.

Systematic overview of current state of the PGx project

Poster presentation at ESHG 2018

Sub-tasks for PGx at Oslo University Hospital

• Making standardized PGx recommendations, using a copy of the Stanford's WebProtégé, at https://www.pgx.no/webprotege
  • Tutorial for curation of guidelines for pharmacogenomics
• Distribution of recommendations by the REST API Pharmacoracle
• Using Next generation sequencing (NGS) for detecting PGx alleles
  • Introducing the Pharmacotyper in our bioinformatic pipeline
• Sorting out challenges with genotyping
  • Finding correct definitions of alleles
  • Evaluate alleles with unknown function
  • Estimate the effect of a variant on gene expression effect of a variant on gene expression
• Integrating PGx decision support in the hospital prescription module by using the Norwegian openEHR framework