The dosing recommendation for patients with an unknown biochemical function allele on at least one chromatid, is to follow the normal medication advice. This means that normal medication is recommended, '''even if the sister-chromatid has ''No function'' or ''Increased function'''''.

This dosing recommendation is very conservative, and the question is whether the allele with ''Unknown function'' should rather be treated as a ''Normal function'' allele(thereby allowing special dosing recommendations for e.g. ''Unknown function''/''No function''-patients).