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→Pharmacoracle - a REST API based on the OWLAPI
==Pharmacoracle - a REST API based on the OWLAPI==
The Pharmacoracle contains OWL ontologies that are based on CPIC recommendations provided by the [https://api.pharmgkb.org PharmGKB API], and which have been further adapted to the needs of the Department of Pharmacology at Oslo University Hospital. The Pharmacoracle was implemented as an attempt to understand the field of pharmacogenomics, based on data from PharmGKB, and solving the same problem as [https://github.com/PharmGKB/PharmCAT/wiki PharmGKBs PharmCAT software], but in the context of the technology and clinical recommendations of our clinic. It may be sensible to integrate PharmCAT in the Pharmacoracle, as soon as PharmCAT becomes the gold standard for VCF to PGx recommendations.
Queries to Pharmacoracle are written in the [https://www.w3.org/TR/owl2-manchester-syntax/ Manchester syntax] in the same way as for the [https://protegewiki.stanford.edu/wiki/DLQueryTab DL Query Tab] of [https://protege.stanford.edu/ Stanford's desktop Protégé]. An advantage of this approach is that the queries replaces the need of a separate rules engine (rules are to some extent built into the OWL semantics). A disadvantage is that the performance in a production environment may be suboptimal (slow).
