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==Alleles with unknown bio-chemical biochemical consequence==There are at least three kind of alleles that have unknown-biochemical function
*Known PGx alleles that are classified with unknown functional status by PharmGKB
*Alleles with variants that cause changes to the protein, but which are not classified by PharmGKB
In the CPIC guidelines, some PGx alleles have unknown bio-chemical biochemical functional status. The dosing recommendation for such patients is to follow the normal medication advice. There are PGx-alleles that are classified with bio-chemical biochemical function, and otherwise, all patients without a known PGx-allele match also have unknown function.
==Alleles with normal bio-chemical consequence==
The bio-chemical function varies for all patients, and [[Normal function]] just means that the functional status is sufficiently close to the mean that the normal medication recommendation can be used.
There are at least two kind of alleles that have normal